Homo sapiens Gene: CD247
Summary
InnateDB Gene IDBG-104547.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD247
Gene Name CD247 molecule
Synonyms CD3-ZETA; CD3H; CD3Q; CD3Z; IMD25; T3Z; TCRZ;
Species Homo sapiens
Ensembl Gene ENSG00000198821
Encoded Proteins
CD247 molecule
CD247 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:167430640-167518610
Strand Reverse strand
Band q24.2
Transcripts
ENST00000362089 ENSP00000354782
ENST00000392122 ENSP00000375969
ENST00000483825
ENST00000485089
ENST00000476733
ENST00000470379
ENST00000479979
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0016032 viral process
GO:0031295 T cell costimulation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0050690 regulation of defense response to virus by virus
GO:0050776 regulation of immune response
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042101 T cell receptor complex
GO:0042105 alpha-beta T cell receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
REACTOME
KEGG
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
Chagas disease (American trypanosomiasis) pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
The co-stimulatory signal during t-cell activation [Biocarta view]
Stathmin and breast cancer resistance to antimicrotubule agents [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Lck and fyn tyrosine kinases in initiation of tcr activation [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
PID NCI
TCR signaling in na´ve CD8+ T cells
CXCR4-mediated signaling events
TCR signaling in na´ve CD4+ T cells
Downstream signaling in na´ve CD8+ T cells
IL12-mediated signaling events
IL12 signaling mediated by STAT4
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.156445 Hs.669326
RefSeq NM_000734 NM_198053
HUGO
OMIM
CCDS CCDS1260 CCDS1261
HPRD 01729
IMGT
EMBL
GenPept
RNA Seq Atlas