Version 5.4
Homo sapiens Gene: CD247
Summary
InnateDB Gene IDBG-104547.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD247
Gene Name CD247 molecule
Synonyms CD3-ZETA; CD3H; CD3Q; CD3Z; IMD25; T3Z; TCRZ
Species Homo sapiens
Ensembl Gene ENSG00000198821
Encoded Proteins
IDBP-104549
CD247 molecule
IDBP-246301
CD247 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:167430640-167518610
Strand Reverse strand
Band q24.2
Transcripts
ENST00000362089 ENSP00000354782
ENST00000392122 ENSP00000375969
ENST00000483825
ENST00000485089
ENST00000476733
ENST00000470379
ENST00000479979
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0016032 viral process
GO:0031295 T cell costimulation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0050690 regulation of defense response to virus by virus
GO:0050776 regulation of immune response
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042101 T cell receptor complex
GO:0042105 alpha-beta T cell receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005763
View Gene Order
ENSBTAG00000012700
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
cxcr4_pathway
CXCR4-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
il12_2pathway
IL12-mediated signaling events
il12_stat4pathway
IL12 signaling mediated by STAT4
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt P20963
TrEMBL A9Y844 B2LYR2 H6QVQ5
UniProt Splice Variant
Entrez Gene 919
UniGene Hs.156445 Hs.669326
RefSeq NM_000734 NM_198053
HUGO HGNC:1677
OMIM 186780
CCDS CCDS1260 CCDS1261
HPRD
IMGT
EMBL AK313946 AL031733 AL359962 BC025703 CH471067 DQ072717 EF364119 EU117371 EU117372 EU117373 EU597245 J04132
GenPept AAA60394 AAH25703 AAY57330 ABQ28690 ABW06577 ABW06578 ABW06579 ACC61185 BAG36664 CAH69974 CAH69975 CAI21380 CAI21381 EAW90792
RNA Seq Atlas 919

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca