InnateDB Protein
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IDBP-246615.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NEU4
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Protein Name
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sialidase 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000375830
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InnateDB Gene
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IDBG-85340 (NEU4)
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Protein Structure
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Function |
May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N- acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids. {ECO:0000269PubMed:14962670, ECO:0000269PubMed:15213228}.
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Subcellular Localization |
Isoform 1: Membrane; Peripheral membrane protein.Isoform 2: Lysosome lumen. Note=According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N- glycosylation site is predicted from the sequence.
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Disease Associations |
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Tissue Specificity |
Ubiquitous with higher expression in heart, skeletal muscle, liver and placenta. {ECO:0000269PubMed:14962670}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011040
Sialidases
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WWR8
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PhosphoSite |
PhosphoSite-Q8WWR8
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TrEMBL |
C9JRN9
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UniProt Splice Variant |
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Entrez Gene |
129807
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UniGene |
Hs.551747
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RefSeq |
NP_001161074
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HUGO |
HGNC:21328
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OMIM |
608527
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CCDS |
CCDS54442
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HPRD |
12249
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IMGT |
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EMBL |
AC114730
AJ277883
AK091038
AK289421
AK300969
AY203952
BC012899
CH471063
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GenPept |
AAH12899
AAP34475
AAX82022
BAF82110
BAG52266
BAH13385
CAC81904
EAW71295
EAW71296
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