InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CALM3

Summary

InnateDB Protein

IDBP-246728.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALM3

Protein Name

calmodulin 3 (phosphorylase kinase, delta)

Synonyms

CALML2; caM; CAMI; CAMII; CPVT4; DD132; HEL-S-72; PHKD; PHKD; PHKD2; PHKD3;

Species

Homo sapiens

Ensembl Protein

ENSP00000375785

InnateDB Gene

IDBG-58805 (CALM3)

Protein Structure

UniProt Annotation

Function

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. {ECO:0000269PubMed:16760425, ECO:0000269PubMed:23893133}.

Subcellular Localization

Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:16760425}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:16760425}. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.

Disease Associations

Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) [MIM:614916]: An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. {ECO:0000269PubMed:23040497}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.