Version 5.4
Homo sapiens Protein: G3BP2
Summary
InnateDB Protein IDBP-24690.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol G3BP2
Protein Name GTPase activating protein (SH3 domain) binding protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000352738
InnateDB Gene IDBG-24688 (G3BP2)
Protein Structure
UniProt Annotation
Function Probable scaffold protein that may be involved in mRNA transport. {ECO:0000305}.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 50 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0030159 receptor signaling complex scaffold activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006810 transport
GO:0007253 cytoplasmic sequestering of NF-kappaB
GO:0007265 Ras protein signal transduction
GO:0051028 mRNA transport
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR002075 Nuclear transport factor 2
IPR018222 Nuclear transport factor 2, eukaryote
PFAM PF00076
PF02136
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UN86
PhosphoSite PhosphoSite-Q9UN86
TrEMBL D6RGJ4
UniProt Splice Variant
Entrez Gene 9908
UniGene Hs.705535
RefSeq NP_987101
HUGO HGNC:30291
OMIM
CCDS CCDS3571
HPRD 06570
IMGT
EMBL AB014560 AC104828 AF051311 AF053535 AF145284 AK291786 BC011731 CH471057
GenPept AAC15705 AAC95292 AAD51932 AAH11731 BAA31635 BAF84475 EAX05742 EAX05743 EAX05744 EAX05746

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca