Version 5.4
Mus musculus Protein: Esco1
Summary
InnateDB Protein IDBP-248707.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Esco1
Protein Name establishment of cohesion 1 homolog 1 (S. cerevisiae)
Synonyms A930014I12Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000111530
InnateDB Gene IDBG-128455 (Esco1)
Protein Structure
UniProt Annotation
Function Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Nuclear at interphase, associated with chromosomes during mitosis. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0016746 transferase activity, transferring acyl groups
GO:0046872 metal ion binding
Biological Process
GO:0006275 regulation of DNA replication
GO:0007062 sister chromatid cohesion
GO:0034421 post-translational protein acetylation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1925055
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q69Z69
PhosphoSite PhosphoSite-Q69Z69
TrEMBL
UniProt Splice Variant
Entrez Gene 77805
UniGene Mm.468860
RefSeq
MGI ID
MGI Symbol Esco1
OMIM
CCDS
HPRD
IMGT
EMBL AC102441 AK045656 AK049589 AK173297 BC008220 BC151069 BC151077
GenPept AAH08220 AAI51070 AAI51078 BAC32447 BAC33830 BAD32575

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca