InnateDB Protein
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IDBP-248713.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rbbp8
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Protein Name
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retinoblastoma binding protein 8
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000111527
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InnateDB Gene
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IDBG-128600 (Rbbp8)
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Protein Structure
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Function |
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations. {ECO:0000269PubMed:20829486, ECO:0000269PubMed:21131978, ECO:0000269PubMed:21131982}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:21131982}. Note=Associates with sites of DNA damage in S/G2 phase. Ubiquitinated RBBP8 binds to chromatin following DNA damage (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
41 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000014
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single-stranded DNA endodeoxyribonuclease activity
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GO:0001103
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RNA polymerase II repressing transcription factor binding
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GO:0001106
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RNA polymerase II transcription corepressor activity
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GO:0003684
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damaged DNA binding
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Biological Process |
GO:0000082
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G1/S transition of mitotic cell cycle
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GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0000724
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double-strand break repair via homologous recombination
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GO:0000737
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DNA catabolic process, endonucleolytic
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GO:0001835
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blastocyst hatching
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GO:0007067
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mitotic nuclear division
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GO:0007126
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meiotic nuclear division
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GO:0010792
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DNA double-strand break processing involved in repair via single-strand annealing
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GO:0031572
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G2 DNA damage checkpoint
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Cellular Component |
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PDB ID |
MGI:2442995
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InterPro |
IPR013882
DNA repair protein Sae2/CtIP
IPR019518
Tumour-suppressor protein CtIP N-terminal
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PFAM |
PF08573
PF10482
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q80YR6
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PhosphoSite |
PhosphoSite-Q80YR6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
225182
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UniGene |
Mm.470817
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RefSeq |
NP_001239424
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MGI ID |
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MGI Symbol |
Rbbp8
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OMIM |
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CCDS |
CCDS37738
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HPRD |
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IMGT |
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EMBL |
AC090479
AC115894
BC050849
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GenPept |
AAH50849
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