InnateDB Protein
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IDBP-248849.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nde1
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Protein Name
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nuclear distribution gene E homolog 1 (A nidulans)
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Synonyms
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2810027M15Rik; AU042936; AW822251; mNudE; Nude;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000111461
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InnateDB Gene
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IDBG-134578 (Nde1)
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Protein Structure
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Function |
Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post- mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. {ECO:0000269PubMed:15473967}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cleavage furrow. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF- dependent manner. Also localizes to the cleavage furrow during cytokinesis.
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Disease Associations |
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Tissue Specificity |
Highly expressed in ovary. Also expressed in brain, heart, kidney, large intestine, liver, lung, small intestine and testis. {ECO:0000269PubMed:11163258, ECO:0000269PubMed:11163259}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1914453
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InterPro |
IPR006964
NUDE protein, C-terminal
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PFAM |
PF04880
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CZA6
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PhosphoSite |
PhosphoSite-Q9CZA6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
67203
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UniGene |
Mm.24105
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RefSeq |
NP_001272432
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MGI ID |
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MGI Symbol |
Nde1
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OMIM |
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CCDS |
CCDS70688
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HPRD |
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IMGT |
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EMBL |
AF290473
AF322073
AK012830
AK037289
AK146982
AK150826
AK169743
BC023267
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GenPept |
AAG10062
AAH23267
AAK08067
BAB28499
BAE20509
BAE27585
BAE29888
BAE41342
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