InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nde1

Summary

InnateDB Gene

IDBG-134578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nde1

Gene Name

nuclear distribution gene E homolog 1 (A nidulans)

Synonyms

2810027M15Rik; AU042936; AW822251; mNudE; Nude

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022678

Encoded Proteins

IDBP-134580

nuclear distribution gene E homolog 1 (A nidulans)

IDBP-248849

nuclear distribution gene E homolog 1 (A nidulans)

IDBP-401637

nuclear distribution gene E homolog 1 (A nidulans)

IDBP-537253

nuclear distribution gene E homolog 1 (A nidulans)

IDBP-538219

nuclear distribution gene E homolog 1 (A nidulans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072864:
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:14163275-14192928

Strand

Forward strand

Band

Transcripts

ENSMUST00000023359	ENSMUSP00000023359
ENSMUST00000115795	ENSMUSP00000111461
ENSMUST00000117958	ENSMUSP00000112817
ENSMUST00000132316	ENSMUSP00000118005
ENSMUST00000133249
ENSMUST00000127801
ENSMUST00000156041
ENSMUST00000149232	ENSMUSP00000119355

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0001764	neuron migration
GO:0007020	microtubule nucleation
GO:0007067	mitotic nuclear division
GO:0007405	neuroblast proliferation
GO:0021987	cerebral cortex development
GO:0030900	forebrain development
GO:0031023	microtubule organizing center organization
GO:0047496	vesicle transport along microtubule
GO:0051298	centrosome duplication
GO:0051303	establishment of chromosome localization

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005874	microtubule
GO:0016020	membrane
GO:0031616	spindle pole centrosome
GO:0032154	cleavage furrow