Mus musculus Protein: Synj2 | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-248859.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Synj2 | ||||||||||||
Protein Name | synaptojanin 2 | ||||||||||||
Synonyms | AI481647; mKIAA0348; SJ2; | ||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Protein | ENSMUSP00000111455 | ||||||||||||
InnateDB Gene | IDBG-133244 (Synj2) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis (By similarity). {ECO:0000250}. | ||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | Ubiquitously expressed, with the highest levels in heart and brain. Detected in cortex, cerebellum and olfactory bulb. Expressed in the testis. {ECO:0000269PubMed:15722415, ECO:0000269PubMed:9442075}. | ||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | MGI:1201671 | ||||||||||||
InterPro |
IPR000300
Inositol polyphosphate-related phosphatase IPR000504 RNA recognition motif domain IPR002013 Synaptojanin, N-terminal IPR005135 Endonuclease/exonuclease/phosphatase IPR015047 Domain of unknown function DUF1866 |
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PFAM |
PF00076
PF02383 PF03372 PF14529 PF08952 |
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PRINTS | |||||||||||||
PIRSF | |||||||||||||
SMART |
SM00128
SM00360 |
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TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q9D2G5 | ||||||||||||
PhosphoSite | PhosphoSite-Q9D2G5 | ||||||||||||
TrEMBL | D3YZB4 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 20975 | ||||||||||||
UniGene | Mm.483121 | ||||||||||||
RefSeq | |||||||||||||
MGI ID | |||||||||||||
MGI Symbol | Synj2 | ||||||||||||
OMIM | |||||||||||||
CCDS | |||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | AC154650 AC168063 AF026123 AF041857 AF041858 AF041859 AF041860 AF041861 AF041862 AK019694 AK129122 BC058749 BC060214 | ||||||||||||
GenPept | AAC33137 AAC40141 AAC40142 AAC40143 AAC40144 AAC40145 AAC40146 AAH58749 AAH60214 BAB31837 BAC97932 | ||||||||||||