Version 5.4
Mus musculus Protein: Synj2
Summary
InnateDB Protein IDBP-248869.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Synj2
Protein Name synaptojanin 2
Synonyms AI481647; mKIAA0348; SJ2;
Species Mus musculus
Ensembl Protein ENSMUSP00000111450
InnateDB Gene IDBG-133244 (Synj2)
Protein Structure
UniProt Annotation
Function Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed, with the highest levels in heart and brain. Detected in cortex, cerebellum and olfactory bulb. Expressed in the testis. {ECO:0000269PubMed:15722415, ECO:0000269PubMed:9442075}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
Biological Process
GO:0046856 phosphatidylinositol dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1201671
InterPro IPR000300 Inositol polyphosphate-related phosphatase
IPR000504 RNA recognition motif domain
IPR002013 Synaptojanin, N-terminal
IPR005135 Endonuclease/exonuclease/phosphatase
IPR015047 Domain of unknown function DUF1866
PFAM PF00076
PF02383
PF03372
PF14529
PF08952
PRINTS
PIRSF
SMART SM00128
SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D2G5
PhosphoSite PhosphoSite-Q9D2G5
TrEMBL
UniProt Splice Variant
Entrez Gene 20975
UniGene Mm.483121
RefSeq
MGI ID
MGI Symbol Synj2
OMIM
CCDS
HPRD
IMGT
EMBL AF026123 AF041857 AF041858 AF041859 AF041860 AF041861 AF041862 AK019694 AK129122 BC058749 BC060214
GenPept AAC33137 AAC40141 AAC40142 AAC40143 AAC40144 AAC40145 AAC40146 AAH58749 AAH60214 BAB31837 BAC97932

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca