Version 5.4
Mus musculus Protein: Pcdhac2
Summary
InnateDB Protein IDBP-249136.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pcdhac2
Protein Name protocadherin alpha 11
Synonyms A830022B16Rik; Cnr1; Cnr3; Cnr7; Cnr8; Crnr1; Crnr3; Crnr7; Crnr8; Pcdha14; R75250;
Species Mus musculus
Ensembl Protein ENSMUSP00000111325
InnateDB Gene IDBG-139382 (Pcdhac2)
Protein Structure
UniProt Annotation
Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:9655502}; Single-pass type I membrane protein {ECO:0000269PubMed:9655502}. Note=Detected in dendrites and synapses.
Disease Associations
Tissue Specificity Detected in brain throughout embryonic development. Detected in adult brain, in particular in cerebellum and forebrain. {ECO:0000269PubMed:9655502}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2681880
InterPro IPR002126 Cadherin
IPR013164 Cadherin, N-terminal
IPR015919 Cadherin-like
PFAM PF00028
PF08266
PRINTS PR00205
PIRSF
SMART SM00112
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88689
PhosphoSite PhosphoSite-
TrEMBL Q8K488
UniProt Splice Variant
Entrez Gene 353237
UniGene Mm.468629
RefSeq NP_031792
MGI ID 1WUZ
MGI Symbol Pcdhac2
OMIM
CCDS CCDS37776
HPRD
IMGT
EMBL AF464178 AF464179 AF464180 AK043822 AK149282 AY013762 BC060211 D86916
GenPept AAH60211 AAK26051 AAM93577 AAM93578 AAM93579 BAA29045 BAC31663 BAE28788

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca