InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHRNA3

Summary

InnateDB Protein

IDBP-24914.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRNA3

Protein Name

cholinergic receptor, nicotinic, alpha 3

Synonyms

LNCR2; NACHRA3; PAOD2;

Species

Homo sapiens

Ensembl Protein

ENSP00000315602

InnateDB Gene

IDBG-24910 (CHRNA3)

Protein Structure

UniProt Annotation

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding
GO:0015276	ligand-gated ion channel activity
GO:0015464	acetylcholine receptor activity
GO:0042166	acetylcholine binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006937	regulation of muscle contraction
GO:0006940	regulation of smooth muscle contraction
GO:0007165	signal transduction
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007268	synaptic transmission
GO:0007271	synaptic transmission, cholinergic
GO:0007399	nervous system development
GO:0007626	locomotory behavior
GO:0014056	regulation of acetylcholine secretion
GO:0034220	ion transmembrane transport
GO:0035095	behavioral response to nicotine
GO:0042391	regulation of membrane potential
GO:0048814	regulation of dendrite morphogenesis
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060084	synaptic transmission involved in micturition

Cellular Component

GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002394 Nicotinic acetylcholine receptor
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02932
PF02931

PRINTS

PR00254
PR00252

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32297