InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHRNA3

Summary

InnateDB Gene

IDBG-24910.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRNA3

Gene Name

cholinergic receptor, nicotinic, alpha 3 (neuronal)

Synonyms

LNCR2; NACHRA3; PAOD2

Species

Homo sapiens

Ensembl Gene

ENSG00000080644

Encoded Proteins

IDBP-24912

cholinergic receptor, nicotinic, alpha 3

IDBP-24914

cholinergic receptor, nicotinic, alpha 3

IDBP-601208

cholinergic receptor, nicotinic, alpha 3

IDBP-594442

cholinergic receptor, nicotinic, alpha 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:78593052-78621295

Strand

Reverse strand

Band

q25.1

Transcripts

ENST00000348639	ENSP00000267951
ENST00000326828	ENSP00000315602
ENST00000559002
ENST00000559658	ENSP00000452896
ENST00000558903
ENST00000561128
ENST00000559080	ENSP00000453993
ENST00000559941

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding
GO:0015276	ligand-gated ion channel activity
GO:0015464	acetylcholine receptor activity
GO:0042166	acetylcholine binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006937	regulation of muscle contraction
GO:0006940	regulation of smooth muscle contraction
GO:0007165	signal transduction
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007268	synaptic transmission
GO:0007271	synaptic transmission, cholinergic
GO:0007399	nervous system development
GO:0007626	locomotory behavior
GO:0014056	regulation of acetylcholine secretion
GO:0034220	ion transmembrane transport
GO:0035095	behavioral response to nicotine
GO:0042391	regulation of membrane potential
GO:0048814	regulation of dendrite morphogenesis
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060084	synaptic transmission involved in micturition

Cellular Component

GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0045211	postsynaptic membrane