Homo sapiens Gene: CHRNA3
Summary
InnateDB Gene IDBG-24910.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHRNA3
Gene Name cholinergic receptor, nicotinic, alpha 3 (neuronal)
Synonyms LNCR2; NACHRA3; PAOD2;
Species Homo sapiens
Ensembl Gene ENSG00000080644
Encoded Proteins
cholinergic receptor, nicotinic, alpha 3
cholinergic receptor, nicotinic, alpha 3
cholinergic receptor, nicotinic, alpha 3
cholinergic receptor, nicotinic, alpha 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78593052-78621295
Strand Reverse strand
Band q25.1
Transcripts
ENST00000348639 ENSP00000267951
ENST00000326828 ENSP00000315602
ENST00000559002
ENST00000559658 ENSP00000452896
ENST00000558903
ENST00000561128
ENST00000559080 ENSP00000453993
ENST00000559941
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004889 acetylcholine-activated cation-selective channel activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005515 protein binding
GO:0015276 ligand-gated ion channel activity
GO:0015464 acetylcholine receptor activity
GO:0042166 acetylcholine binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006937 regulation of muscle contraction
GO:0006940 regulation of smooth muscle contraction
GO:0007165 signal transduction
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007268 synaptic transmission
GO:0007271 synaptic transmission, cholinergic
GO:0007399 nervous system development
GO:0007626 locomotory behavior
GO:0014056 regulation of acetylcholine secretion
GO:0034220 ion transmembrane transport
GO:0035095 behavioral response to nicotine
GO:0042391 regulation of membrane potential
GO:0048814 regulation of dendrite morphogenesis
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060084 synaptic transmission involved in micturition
Cellular Component
GO:0005886 plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Neuronal System pathway
Highly calcium permeable nicotinic acetylcholine receptors pathway
Postsynaptic nicotinic acetylcholine receptors pathway
Highly sodium permeable acetylcholine nicotinic receptors pathway
Activation of Nicotinic Acetylcholine Receptors pathway
Presynaptic nicotinic acetylcholine receptors pathway
Transmission across Chemical Synapses pathway
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Acetylcholine Binding And Downstream Events pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.89605
RefSeq NM_000743 NM_001166694
HUGO
OMIM
CCDS CCDS10305 CCDS53964
HPRD 07511
IMGT
EMBL
GenPept
RNA Seq Atlas