Mus musculus Protein: Kdm4d
Summary
InnateDB Protein IDBP-249177.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kdm4d
Protein Name lysine (K)-specific demethylase 4D
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000111311
InnateDB Gene IDBG-134411 (Kdm4d)
Protein Structure
UniProt Annotation
Function Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys- 9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00537}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Protein Structure and Domains
PDB ID MGI:3606484
InterPro IPR003347 JmjC domain
IPR003349 Transcription factor jumonji, JmjN
PFAM PF02373
PF08007
PF02375
PRINTS
PIRSF
SMART SM00558
SM00545
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Z4YLE9
UniProt Splice Variant
Entrez Gene 244694
UniGene Mm.240457
RefSeq
MGI ID
MGI Symbol Kdm4d
OMIM
CCDS
HPRD
IMGT
EMBL CT485607
GenPept