InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MIF

Summary

InnateDB Protein

IDBP-2495.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MIF

Protein Name

macrophage migration inhibitory factor (glycosylation-inhibiting factor)

Synonyms

GIF; GLIF; MMIF;

Species

Homo sapiens

Ensembl Protein

ENSP00000215754

InnateDB Gene

IDBG-401910 (MIF)

Protein Structure

UniProt Annotation

Function

Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. {ECO:0000269PubMed:15908412, ECO:0000269PubMed:17443469, ECO:0000269PubMed:23776208}.

Subcellular Localization

Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non- classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.

Disease Associations

Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic- onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004167	dopachrome isomerase activity
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005515	protein binding
GO:0016853	isomerase activity
GO:0042056	chemoattractant activity
GO:0050178	phenylpyruvate tautomerase activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0001934	positive regulation of protein phosphorylation
GO:0002906	negative regulation of mature B cell apoptotic process
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007569	cell aging
GO:0008283	cell proliferation
GO:0010629	negative regulation of gene expression
GO:0010739	positive regulation of protein kinase A signaling
GO:0019752	carboxylic acid metabolic process
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0030890	positive regulation of B cell proliferation
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0032269	negative regulation of cellular protein metabolic process
GO:0033033	negative regulation of myeloid cell apoptotic process
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042127	regulation of cell proliferation
GO:0042327	positive regulation of phosphorylation
GO:0043030	regulation of macrophage activation
GO:0043066	negative regulation of apoptotic process
GO:0043406	positive regulation of MAP kinase activity
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087	innate immune response (InnateDB)
GO:0048146	positive regulation of fibroblast proliferation
GO:0050715	positive regulation of cytokine secretion
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0061078	positive regulation of prostaglandin secretion involved in immune response
GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response
GO:0070207	protein homotrimerization
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071157	negative regulation of cell cycle arrest
GO:0090238	positive regulation of arachidonic acid secretion
GO:0090344	negative regulation of cell aging
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production