InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD180

Summary

InnateDB Protein

IDBP-24970.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD180

Protein Name

CD180 molecule

Synonyms

LY64; Ly78; RP105;

Species

Homo sapiens

Ensembl Protein

ENSP00000256447

InnateDB Gene

IDBG-24968 (CD180)

Protein Structure

UniProt Annotation

Function

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002322	B cell proliferation involved in immune response
GO:0006954	inflammatory response
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0071222	cellular response to lipopolysaccharide