InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il1r1

Summary

InnateDB Protein

IDBP-251035.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Il1r1

Protein Name

interleukin 1 receptor, type I

Synonyms

CD121a; CD121b; IL-1R1; IL-iR; Il1r-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110443

InnateDB Gene

IDBG-148254 (Il1r1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	13 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004908	interleukin-1 receptor activity
GO:0004909	interleukin-1, Type I, activating receptor activity
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0050727	regulation of inflammatory response
GO:0070498	interleukin-1-mediated signaling pathway

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

MGI:96545

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR003599 Immunoglobulin subtype
IPR004074 Interleukin-1 receptor type I/II
IPR004076 Interleukin-1 receptor type 1
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM

PF01582
PF13676
PF07679

PRINTS

PR01536
PR01538

PIRSF

SMART

SM00255
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt