Version 5.4
| Mus musculus Gene: Il1r1 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-148254.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Il1r1 | ||||||||||||||||||||||
| Gene Name | interleukin 1 receptor, type I | ||||||||||||||||||||||
| Synonyms | CD121a; CD121b; IL-1R1; IL-iR; Il1r-1 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000026072 | ||||||||||||||||||||||
| Encoded Proteins |
interleukin 1 receptor, type I
interleukin 1 receptor, type I
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||
| Summary |
Il1r1 is the primary receptor for the inflammatory cytokine Il1b. (Demonstrated in human)
IL1R1 upregulates Mir135b as a negative feedback regulatory mechanism to resolve cigarette smoke-induced inflammation in the lung.
In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.
Adam17 affects sensitivity to interleukin-1 by changing the balance between Il1r1 and Il1r2 receptors.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Homo sapiens] IL1R1 is a substrate for presenilin-dependent gamma-secretase cleavage and intramembrane proteolysis may be a control mechanism for IL1R1-mediated signalling.
[Homo sapiens] IL1R1 is essential for TLR9-dependent activation of tumour necrosis factor receptor-associated factor 3 (TRAF3) and for production of the anti-inflammatory cytokines IL-10 and type I interferon (IFN).
[Homo sapiens] IL1R1 is the primary receptor for the inflammatory cytokine IL1B.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115594:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008] This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 1:40225080-40316198 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | B | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
Interleukin-1 signaling pathway
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| KEGG |
Cytokine-cytokine receptor interaction pathway
Hematopoietic cell lineage pathway
MAPK signaling pathway pathway
Apoptosis pathway
Amoebiasis pathway
Osteoclast differentiation pathway
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| INOH |
IL-1 signaling pathway pathway
JAK STAT pathway and regulation pathway
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| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
IL1 pathway
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| REACTOME |
Interleukin-1 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
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| KEGG |
Hematopoietic cell lineage pathway
Apoptosis pathway
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Amoebiasis pathway
Osteoclast differentiation pathway
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| INOH |
IL-1 signaling pathway pathway
JAK STAT pathway and regulation pathway
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| PID NCI |
IL1-mediated signaling events
IL12-mediated signaling events
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| Cross-References | |||||||||||||||||||||||
| SwissProt | P13504 | ||||||||||||||||||||||
| TrEMBL | Q32MH0 Q8C833 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 16177 | ||||||||||||||||||||||
| UniGene | Mm.420806 Mm.472432 Mm.896 | ||||||||||||||||||||||
| RefSeq | NM_008362 XM_006495713 NM_001123382 XM_006495714 XM_006495715 XM_006495716 XM_006495717 XM_006495718 XM_006495719 XM_006495720 XM_006495721 XM_006495722 XM_006495723 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS35547 CCDS48246 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:96545 | ||||||||||||||||||||||
| MGI Symbol | Il1r1 | ||||||||||||||||||||||
| EMBL | AC135085 AC167168 AK048550 BC109135 CH466536 M20658 | ||||||||||||||||||||||
| GenPept | AAA39279 AAI09136 BAC33372 EDL14572 | ||||||||||||||||||||||
| RNA Seq Atlas | 16177 | ||||||||||||||||||||||