InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nck2

Summary

InnateDB Protein

IDBP-251123.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nck2

Protein Name

non-catalytic region of tyrosine kinase adaptor protein 2

Synonyms

4833426I10Rik; Grb4; Nck-2; NCKbeta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110392

InnateDB Gene

IDBG-149650 (Nck2)

Protein Structure

UniProt Annotation

Function

Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006417	regulation of translation
GO:0007015	actin filament organization
GO:0016477	cell migration
GO:0030032	lamellipodium assembly
GO:0030838	positive regulation of actin filament polymerization
GO:0042102	positive regulation of T cell proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0012506	vesicle membrane

Protein Structure and Domains

PDB ID

MGI:1306821

InterPro

IPR001452 SH3 domain
IPR011511 Variant SH3 domain

PFAM

PF00018
PF14604
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O55033

PhosphoSite

PhosphoSite-O55033

TrEMBL

UniProt Splice Variant

Entrez Gene

17974

UniGene

Mm.483157

RefSeq

MGI ID

MGI Symbol

Nck2

OMIM

CCDS

HPRD

IMGT

EMBL

AC107865 AC108914 AF043260 BC011071 BC034255 CH466589

GenPept

AAC06353 AAH11071 AAH34255 EDK96908