InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmprss3

Summary

InnateDB Protein

IDBP-251533.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmprss3

Protein Name

transmembrane protease, serine 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110196

InnateDB Gene

IDBG-163886 (Tmprss3)

Protein Structure

UniProt Annotation

Function

Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro). {ECO:0000269PubMed:12393794, ECO:0000269PubMed:21454591}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12393794, ECO:0000269PubMed:21454591}; Single-pass type II membrane protein {ECO:0000269PubMed:12393794, ECO:0000269PubMed:21454591}.

Disease Associations

Tissue Specificity

Strongly expressed in liver, cochlea, brain, cerebellum, spleen, lung, and muscle and at a lower degree in retina, kidney, and heart. Expressed in the spiral ganglion, the cells supporting the organ of Corti and the stria vascularis. Isoform 2 is strongly expressed only in the cochlea with very faint expression in the cerebellum, spleen and muscle. {ECO:0000269PubMed:21454591}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity

Biological Process

GO:0006508	proteolysis
GO:0006883	cellular sodium ion homeostasis
GO:0006898	receptor-mediated endocytosis
GO:0007605	sensory perception of sound

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:2155445

InterPro

IPR001190 SRCR domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
IPR017448 SRCR-like domain

PFAM

PF00530
PF00089
PF00057
PF09342

PRINTS

PR00258
PR00722
PR00261

PIRSF

SMART

SM00020
SM00192
SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt