Version 5.4
Mus musculus Protein: Slc6a8
Summary
InnateDB Protein IDBP-251704.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc6a8
Protein Name solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Synonyms AA589632; Creat; CRT; CRTR; CT1; CTR5;
Species Mus musculus
Ensembl Protein ENSMUSP00000110111
InnateDB Gene IDBG-153261 (Slc6a8)
Protein Structure
UniProt Annotation
Function Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier.
Subcellular Localization Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005309 creatine:sodium symporter activity
GO:0005328 neurotransmitter:sodium symporter activity
GO:0015220 choline transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0006836 neurotransmitter transport
GO:0015871 choline transport
GO:1902598 creatine transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2147834
InterPro IPR000175 Sodium:neurotransmitter symporter
IPR002984 Sodium:neurotransmitter symporter, creatine
PFAM PF00209
PRINTS PR00176
PR01199
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VBW1
PhosphoSite PhosphoSite-Q8VBW1
TrEMBL E9Q6T2
UniProt Splice Variant
Entrez Gene 102857
UniGene Mm.274553
RefSeq
MGI ID
MGI Symbol Slc6a8
OMIM
CCDS CCDS53098
HPRD
IMGT
EMBL AB077327 AF459435 AF459436 AL805924 BC024444 BC049801 BC141067 BC145319 EU523148
GenPept AAH24444 AAH49801 AAI41068 AAI45320 AAL66354 AAL66355 ACC77954 BAC11857 CAM21057

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca