Version 5.4
Mus musculus Gene: Slc6a8
Summary
InnateDB Gene IDBG-153261.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc6a8
Gene Name solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Synonyms AA589632; Creat; CRT; CRTR; CT1; CTR5
Species Mus musculus
Ensembl Gene ENSMUSG00000019558
Encoded Proteins
IDBP-153263
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
IDBP-251704
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
IDBP-251706
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
IDBP-251708
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
IDBP-625695
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
IDBP-625698
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
IDBP-625699
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130821:
The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:73673150-73682502
Strand Forward strand
Band A7.3
Transcripts
ENSMUST00000033752 ENSMUSP00000033752
ENSMUST00000114467 ENSMUSP00000110111
ENSMUST00000114465 ENSMUSP00000110109
ENSMUST00000114464 ENSMUSP00000110108
ENSMUST00000146796
ENSMUST00000164449 ENSMUSP00000126076
ENSMUST00000168831 ENSMUSP00000132921
ENSMUST00000171398 ENSMUSP00000128079
ENSMUST00000168764
ENSMUST00000170614
ENSMUST00000166200
ENSMUST00000170574
ENSMUST00000167828
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005308 creatine transmembrane transporter activity
GO:0005309 creatine:sodium symporter activity
GO:0005328 neurotransmitter:sodium symporter activity
GO:0015220 choline transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0006836 neurotransmitter transport
GO:0015871 choline transport
GO:0015881 creatine transport
GO:1902598 creatine transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130821
View Gene Order
ENSBTAG00000009959
Not yet available
Pathways
NETPATH
REACTOME
REACT_239426
Creatine metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_813
Creatine metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_226362
Metabolism of amino acids and derivatives pathway
REACT_207339
Creatine metabolism pathway
REACT_219139
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.274553
RefSeq NM_001142809 NM_001142810 NM_133987
OMIM
CCDS CCDS30208 CCDS53098
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca