Version 5.4
Mus musculus Protein: Gng12
Summary
InnateDB Protein IDBP-252212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gng12
Protein Name guanine nucleotide binding protein (G protein), gamma 12
Synonyms 2010305F15Rik; AA536815; AI115529; AI314170; AI842738;
Species Mus musculus
Ensembl Protein ENSMUSP00000109863
InnateDB Gene IDBG-153698 (Gng12)
Protein Structure
UniProt Annotation
Function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0030165 PDZ domain binding
GO:0042301 phosphate ion binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0021987 cerebral cortex development
GO:0032496 response to lipopolysaccharide
Cellular Component
GO:0005834 heterotrimeric G-protein complex
GO:0005884 actin filament
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1336171
InterPro IPR001770 G-protein, gamma subunit
IPR015898 G-protein gamma-like domain
PFAM PF00631
PRINTS PR00321
PIRSF
SMART SM00224
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DAS9
PhosphoSite PhosphoSite-Q9DAS9
TrEMBL
UniProt Splice Variant
Entrez Gene 14701
UniGene Mm.472558
RefSeq NP_001171027
MGI ID
MGI Symbol Gng12
OMIM
CCDS CCDS39502
HPRD
IMGT
EMBL AK005561 AK033422 AK148765 AK159872 AK162342 AK166035 AK166299 BC040685
GenPept AAH40685 BAB24121 BAC28280 BAE28660 BAE35445 BAE36863 BAE38536 BAE38688

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca