InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tiam1

Summary

InnateDB Protein

IDBP-252404.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tiam1

Protein Name

T-cell lymphoma invasion and metastasis 1

Synonyms

AI847750; D16Ium10; D16Ium10e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109759

InnateDB Gene

IDBG-174466 (Tiam1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0046875	ephrin receptor binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0016477	cell migration
GO:0016601	Rac protein signal transduction
GO:0032314	regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043087	regulation of GTPase activity
GO:0048013	ephrin receptor signaling pathway
GO:0050772	positive regulation of axonogenesis

Cellular Component

GO:0005886	plasma membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0044291	cell-cell contact zone

Protein Structure and Domains

PDB ID

MGI:103306

InterPro

IPR000219 Dbl homology (DH) domain
IPR001478 PDZ domain
IPR001849 Pleckstrin homology domain
IPR003116 Raf-like Ras-binding
IPR029071 Ubiquitin-related domain

PFAM

PF00621
PF00595
PF13180
PF00169
PF02196

PRINTS

PIRSF

SMART

SM00325
SM00228
SM00233
SM00455

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite