InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ubr2

Summary

InnateDB Protein

IDBP-254037.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ubr2

Protein Name

ubiquitin protein ligase E3 component n-recognin 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108963

InnateDB Gene

IDBG-188567 (Ubr2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14585983, ECO:0000269PubMed:20080676}. Note=Associated with chromatin during meiosis.

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle. Also expressed in heart, kidney and testis. Expressed in acinar cells of the pancreas. In testes, expressed primarily in spermatocytes. {ECO:0000269PubMed:14585983, ECO:0000269PubMed:15548684, ECO:0000269PubMed:16311597}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0070728	leucine binding

Biological Process

GO:0006342	chromatin silencing
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007141	male meiosis I
GO:0007283	spermatogenesis
GO:0030163	protein catabolic process
GO:0032007	negative regulation of TOR signaling
GO:0033522	histone H2A ubiquitination
GO:0071233	cellular response to leucine

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1861099

InterPro

IPR003126 Zinc finger, N-recognin
IPR003769 Adaptor protein ClpS, core
IPR013993 Zinc finger, N-recognin, metazoa
IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like

PFAM

PF02207
PF02617

PRINTS

PIRSF

SMART

SM00396

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6WKZ8