InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mark2

Summary

InnateDB Protein

IDBP-254042.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mark2

Protein Name

MAP/microtubule affinity-regulating kinase 2

Synonyms

Emk; EMK-1; Par-1; Par-1b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108969

InnateDB Gene

IDBG-138576 (Mark2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	56 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0050321	tau-protein kinase activity

Biological Process

GO:0001764	neuron migration
GO:0006468	protein phosphorylation
GO:0010976	positive regulation of neuron projection development
GO:0030010	establishment of cell polarity
GO:0035556	intracellular signal transduction
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0046777	protein autophosphorylation
GO:0050770	regulation of axonogenesis
GO:0051493	regulation of cytoskeleton organization

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane
GO:0045180	basal cortex

Protein Structure and Domains

PDB ID

MGI:99638

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001772 Kinase associated domain 1 (KA1)
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR028375 KA1 domain/Ssp2 C-terminal domain

PFAM

PF00069
PF07714
PF02149

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00165
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt