Version 5.4
Mus musculus Gene: Mark2
Summary
InnateDB Gene IDBG-138576.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mark2
Gene Name MAP/microtubule affinity-regulating kinase 2
Synonyms Emk; EMK-1; Par-1; Par-1b
Species Mus musculus
Ensembl Gene ENSMUSG00000024969
Encoded Proteins
IDBP-138578
MAP/microtubule affinity-regulating kinase 2
IDBP-138582
MAP/microtubule affinity-regulating kinase 2
IDBP-254042
MAP/microtubule affinity-regulating kinase 2
IDBP-619874
MAP/microtubule affinity-regulating kinase 2
IDBP-619875
MAP/microtubule affinity-regulating kinase 2
IDBP-619876
MAP/microtubule affinity-regulating kinase 2
IDBP-619877
MAP/microtubule affinity-regulating kinase 2
IDBP-619878
MAP/microtubule affinity-regulating kinase 2
IDBP-619879
MAP/microtubule affinity-regulating kinase 2
IDBP-619880
MAP/microtubule affinity-regulating kinase 2
IDBP-619881
MAP/microtubule affinity-regulating kinase 2
IDBP-619882
MAP/microtubule affinity-regulating kinase 2
IDBP-619883
MAP/microtubule affinity-regulating kinase 2
IDBP-619884
MAP/microtubule affinity-regulating kinase 2
IDBP-619885
MAP/microtubule affinity-regulating kinase 2
IDBP-619886
MAP/microtubule affinity-regulating kinase 2
IDBP-619887
MAP/microtubule affinity-regulating kinase 2
IDBP-619888
MAP/microtubule affinity-regulating kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072518:
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:7275396-7341860
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025921 ENSMUSP00000025921
ENSMUST00000032557 ENSMUSP00000032557
ENSMUST00000051711 ENSMUSP00000108969
ENSMUST00000164205 ENSMUSP00000127827
ENSMUST00000171721 ENSMUSP00000129506
ENSMUST00000165965 ENSMUSP00000131684
ENSMUST00000166461 ENSMUSP00000128549
ENSMUST00000165286 ENSMUSP00000126468
ENSMUST00000171044
ENSMUST00000168872 ENSMUSP00000128560
ENSMUST00000167767 ENSMUSP00000132482
ENSMUST00000165881 ENSMUSP00000126753
ENSMUST00000171352 ENSMUSP00000129490
ENSMUST00000163345 ENSMUSP00000125944
ENSMUST00000164129 ENSMUSP00000129067
ENSMUST00000170768
ENSMUST00000168852
ENSMUST00000171393 ENSMUSP00000129894
ENSMUST00000169541 ENSMUSP00000128779
ENSMUST00000165989 ENSMUSP00000129924
ENSMUST00000168324 ENSMUSP00000131266
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 56 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0044822 poly(A) RNA binding
GO:0050321 tau-protein kinase activity
Biological Process
GO:0001764 neuron migration
GO:0006468 protein phosphorylation
GO:0010976 positive regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0030010 establishment of cell polarity
GO:0035556 intracellular signal transduction
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0046777 protein autophosphorylation
GO:0050770 regulation of axonogenesis
GO:0051493 regulation of cytoskeleton organization
Cellular Component
GO:0005634 nucleus
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016328 lateral plasma membrane
GO:0045180 basal cortex
GO:0097427 microtubule bundle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000072518
View Gene Order
ENSBTAG00000007825
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
lkb1_pathway
LKB1 signaling events
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.258986 Mm.487889
RefSeq NM_001080388 NM_001080389 NM_001080390 NM_007928 XM_006526648 XM_006526652 XM_006526655
OMIM
CCDS CCDS37903 CCDS37904 CCDS37905 CCDS50378
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca