Version 5.4
Mus musculus Protein: Trem2
Summary
InnateDB Protein IDBP-254323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trem2
Protein Name triggering receptor expressed on myeloid cells 2
Synonyms TREM-2; Trem2a; Trem2b; Trem2c;
Species Mus musculus
Ensembl Protein ENSMUSP00000108863
InnateDB Gene IDBG-189871 (Trem2)
Protein Structure
UniProt Annotation
Function May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. {ECO:0000269PubMed:11241283}.
Subcellular Localization Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 2: Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed at higher levels in the CNS, heart and lung than in lymph nodes or in other non-lymphoid tissues such as kidney, liver and testis. In the CNS not all microglia express TREM2. Brain regions with an incomplete blood-brain barrier had the lowest percentages of TREM2 expressing microglia, whereas the lateral entorhinal and cingulate cortex had the highest percentages. {ECO:0000269PubMed:11241283, ECO:0000269PubMed:12472885}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1913150
InterPro IPR003599 Immunoglobulin subtype
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99NH8
PhosphoSite PhosphoSite-Q99NH8
TrEMBL
UniProt Splice Variant
Entrez Gene 83433
UniGene Mm.439016
RefSeq NP_001259007
MGI ID
MGI Symbol Trem2
OMIM
CCDS CCDS70825
HPRD
IMGT
EMBL AF213458 AK039477 AY024348 AY024349 AY187009 BC032959 BC033485 BC052784
GenPept AAF69825 AAH32959 AAH33485 AAH52784 AAK01465 AAK01466 AAO06114 BAC30362

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca