InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cxcl12

Summary

InnateDB Protein

IDBP-255076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcl12

Protein Name

chemokine (C-X-C motif) ligand 12

Synonyms

Pbsf; Scyb12; Sdf1; Tlsf; Tpar1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108492

InnateDB Gene

IDBG-180998 (Cxcl12)

Protein Structure

UniProt Annotation

Function

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. {ECO:0000250}.Stimulates the proliferation of bone marrow-derived b progenitor cells in the presence of IL-7 as well as growth of the stromal cell-dependent B-cell clone DW34 cells.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highest expression levels detected in kidney, liver, spleen and muscle. Isoform Alpha is expressed ubiquitously but at varying levels, while isoform Beta displays tissue-specific expression, with expression detected in kidney, liver, heart, spleen and muscle but not in lung, colon, brain, skin and stomach. {ECO:0000269PubMed:7982471}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0008083	growth factor activity
GO:0042379	chemokine receptor binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001667	ameboidal cell migration
GO:0006955	immune response
GO:0007281	germ cell development
GO:0007420	brain development
GO:0008045	motor neuron axon guidance
GO:0008354	germ cell migration
GO:0030334	regulation of cell migration
GO:0030335	positive regulation of cell migration
GO:0042098	T cell proliferation
GO:0045785	positive regulation of cell adhesion
GO:0050930	induction of positive chemotaxis
GO:0060326	cell chemotaxis
GO:2000406	positive regulation of T cell migration