InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cxcl12

Summary

InnateDB Gene

IDBG-180998.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcl12

Gene Name

chemokine (C-X-C motif) ligand 12

Synonyms

Pbsf; Scyb12; Sdf1; Tlsf; Tpar1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000061353

Encoded Proteins

IDBP-181000

chemokine (C-X-C motif) ligand 12

IDBP-255076

chemokine (C-X-C motif) ligand 12

IDBP-255078

chemokine (C-X-C motif) ligand 12

IDBP-789562

chemokine (C-X-C motif) ligand 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24000293

[Homo sapiens] MIR141 directly regulates CXCL12 expression and CXCL12 mediated leukocyte migration during colonic inflammation.

Entrez Gene

Summary

The protein encoded by this gene is a member of the intercrine-macrophage inflammatory protein superfamily. It is a secreted protein thought to be involved in the generation and proliferation of early B-cell progenitors. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:117168535-117181367

Strand

Forward strand

Band

Transcripts

ENSMUST00000073043	ENSMUSP00000072800
ENSMUST00000112871	ENSMUSP00000108492
ENSMUST00000112866	ENSMUSP00000108487
ENSMUST00000134244
ENSMUST00000185648	ENSMUSP00000140441

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0008083	growth factor activity
GO:0042379	chemokine receptor binding
GO:0045236	CXCR chemokine receptor binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001666	response to hypoxia
GO:0001667	ameboidal cell migration
GO:0001764	neuron migration
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006955	immune response
GO:0007281	germ cell development
GO:0007420	brain development
GO:0008045	motor neuron axon guidance
GO:0008284	positive regulation of cell proliferation
GO:0008344	adult locomotory behavior
GO:0008354	germ cell migration
GO:0009314	response to radiation
GO:0009408	response to heat
GO:0009612	response to mechanical stimulus
GO:0022029	telencephalon cell migration
GO:0030334	regulation of cell migration
GO:0030335	positive regulation of cell migration
GO:0031100	organ regeneration
GO:0033603	positive regulation of dopamine secretion
GO:0042098	T cell proliferation
GO:0043434	response to peptide hormone
GO:0045666	positive regulation of neuron differentiation
GO:0045785	positive regulation of cell adhesion
GO:0048842	positive regulation of axon extension involved in axon guidance
GO:0050930	induction of positive chemotaxis
GO:0051924	regulation of calcium ion transport
GO:0060326	cell chemotaxis
GO:0070098	chemokine-mediated signaling pathway
GO:0090026	positive regulation of monocyte chemotaxis
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000107	negative regulation of leukocyte apoptotic process
GO:2000406	positive regulation of T cell migration

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0070062	extracellular vesicular exosome