Mus musculus Gene: Cxcl12
Summary
InnateDB Gene IDBG-180998.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cxcl12
Gene Name chemokine (C-X-C motif) ligand 12
Synonyms Pbsf; Scyb12; Sdf1; Tlsf; Tpar1;
Species Mus musculus
Ensembl Gene ENSMUSG00000061353
Encoded Proteins
chemokine (C-X-C motif) ligand 12
chemokine (C-X-C motif) ligand 12
chemokine (C-X-C motif) ligand 12
chemokine (C-X-C motif) ligand 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] MIR141 directly regulates CXCL12 expression and CXCL12 mediated leukocyte migration during colonic inflammation.
Entrez Gene
Summary The protein encoded by this gene is a member of the intercrine-macrophage inflammatory protein superfamily. It is a secreted protein thought to be involved in the generation and proliferation of early B-cell progenitors. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:117168535-117181367
Strand Forward strand
Band F1
Transcripts
ENSMUST00000073043 ENSMUSP00000072800
ENSMUST00000112871 ENSMUSP00000108492
ENSMUST00000112866 ENSMUSP00000108487
ENSMUST00000134244
ENSMUST00000185648 ENSMUSP00000140441
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
GO:0008083 growth factor activity
GO:0042379 chemokine receptor binding
GO:0045236 CXCR chemokine receptor binding
Biological Process
GO:0001569 patterning of blood vessels
GO:0001666 response to hypoxia
GO:0001667 ameboidal cell migration
GO:0001764 neuron migration
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006955 immune response
GO:0007281 germ cell development
GO:0007420 brain development
GO:0008045 motor neuron axon guidance
GO:0008284 positive regulation of cell proliferation
GO:0008344 adult locomotory behavior
GO:0008354 germ cell migration
GO:0009314 response to radiation
GO:0009408 response to heat
GO:0009612 response to mechanical stimulus
GO:0022029 telencephalon cell migration
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0031100 organ regeneration
GO:0033603 positive regulation of dopamine secretion
GO:0042098 T cell proliferation
GO:0043434 response to peptide hormone
GO:0045666 positive regulation of neuron differentiation
GO:0045785 positive regulation of cell adhesion
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0050930 induction of positive chemotaxis
GO:0051924 regulation of calcium ion transport
GO:0060326 cell chemotaxis
GO:0070098 chemokine-mediated signaling pathway
GO:0090026 positive regulation of monocyte chemotaxis
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000107 negative regulation of leukocyte apoptotic process
GO:2000406 positive regulation of T cell migration
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Nuclear signaling by ERBB4 pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by ERBB4 pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
G alpha (i) signalling events pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
Axon guidance pathway
Leukocyte transendothelial migration pathway
Intestinal immune network for IgA production pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signaling by ERBB4 pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
Nuclear signaling by ERBB4 pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
Axon guidance pathway
Leukocyte transendothelial migration pathway
Intestinal immune network for IgA production pathway
INOH
PID BIOCARTA
Role of ?-arrestins in the activation and targeting of map kinases [Biocarta view]
Corticosteroids and cardioprotection [Biocarta view]
Cxcr4 signaling pathway [Biocarta view]
Cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway [Biocarta view]
Ss-arrestins in gpcr desensitization [Biocarta view]
G-protein signaling through tubby proteins [Biocarta view]
Pertussis toxin-insensitive ccr5 signaling in macrophage [Biocarta view]
Chrebp regulation by carbohydrates and camp [Biocarta view]
Activation of camp-dependent protein kinase pka [Biocarta view]
Roles of ? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
Ion channels and their functional role in vascular endothelium [Biocarta view]
Activation of pkc through g-protein coupled receptors [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
PID NCI
CXCR4-mediated signaling events
HIF-1-alpha transcription factor network
Syndecan-4-mediated signaling events
Cross-References
SwissProt
TrEMBL H7BX38
UniProt Splice Variant
Entrez Gene 20315
UniGene Mm.303231 Mm.407920
RefSeq NM_001012477 NM_013655 NM_021704
OMIM
CCDS CCDS20463 CCDS39605 CCDS39606
HPRD
IMGT
MGI ID MGI:103556
MGI Symbol Cxcl12
EMBL AC155646
GenPept
RNA Seq Atlas 20315