InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Brdt

Summary

InnateDB Protein

IDBP-255506.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Brdt

Protein Name

bromodomain, testis-specific

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108297

InnateDB Gene

IDBG-186768 (Brdt)

Protein Structure

UniProt Annotation

Function

Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. {ECO:0000269PubMed:12861021, ECO:0000269PubMed:19794495, ECO:0000269PubMed:22570411, ECO:0000269PubMed:22901802, ECO:0000269PubMed:22922464}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17728347, ECO:0000269PubMed:19794495, ECO:0000269PubMed:22020252}. Note=Detected on chromatin. Excluded from the chromocenter.

Disease Associations

Tissue Specificity

Testis-specific. Expressed in germinal cells from the early meiotic (pachytene) spermatocytes and during spermiogenesis in the round and elongating spermatids until the condensed late spermatids. No expression seen in spermatogonia. {ECO:0000269PubMed:15261828, ECO:0000269PubMed:17049203, ECO:0000269PubMed:17728347}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042393	histone binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0001207	histone displacement
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006397	mRNA processing
GO:0007140	male meiosis
GO:0007141	male meiosis I
GO:0007283	spermatogenesis
GO:0008380	RNA splicing
GO:0030154	cell differentiation
GO:0043484	regulation of RNA splicing
GO:0051039	positive regulation of transcription during meiosis