Mus musculus Protein: Phf8 | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-255511.7 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | Phf8 | ||||||
Protein Name | PHD finger protein 8 | ||||||
Synonyms | |||||||
Species | Mus musculus | ||||||
Ensembl Protein | ENSMUSP00000108289 | ||||||
InnateDB Gene | IDBG-179199 (Phf8) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3 (By similarity). {ECO:0000250}. | ||||||
Subcellular Localization | Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Recruited to H3K4me3 sites on chromatin during interphase. Dissociates from chromatin when cells enter mitosis (By similarity). {ECO:0000250}. | ||||||
Disease Associations | |||||||
Tissue Specificity | |||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | MGI:2444341 | ||||||
InterPro |
IPR001965
Zinc finger, PHD-type IPR003347 JmjC domain IPR011011 Zinc finger, FYVE/PHD-type IPR019787 Zinc finger, PHD-finger |
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PFAM |
PF02373
PF08007 PF00628 |
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PRINTS | |||||||
PIRSF | |||||||
SMART |
SM00249
SM00558 |
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TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | |||||||
PhosphoSite | PhosphoSite-Q80TJ7 | ||||||
TrEMBL | Z4YL84 | ||||||
UniProt Splice Variant | |||||||
Entrez Gene | 320595 | ||||||
UniGene | Mm.474866 | ||||||
RefSeq | |||||||
MGI ID | |||||||
MGI Symbol | Phf8 | ||||||
OMIM | |||||||
CCDS | |||||||
HPRD | |||||||
IMGT | |||||||
EMBL | AL662922 AL840642 | ||||||
GenPept | |||||||