InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Phf8

Summary

InnateDB Gene

IDBG-179199.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phf8

Gene Name

PHD finger protein 8

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041229

Encoded Proteins

IDBP-179201

PHD finger protein 8

IDBP-179203

PHD finger protein 8

IDBP-255511

PHD finger protein 8

IDBP-255513

PHD finger protein 8

IDBP-255515

PHD finger protein 8

IDBP-255517

PHD finger protein 8

IDBP-533559

PHD finger protein 8

IDBP-540376

PHD finger protein 8

IDBP-625517

PHD finger protein 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172943:
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:151520672-151633859

Strand

Forward strand

Band

Transcripts

ENSMUST00000046962	ENSMUSP00000041312
ENSMUST00000046950	ENSMUSP00000040765
ENSMUST00000112670	ENSMUSP00000108289
ENSMUST00000112668	ENSMUSP00000108287
ENSMUST00000112666	ENSMUSP00000108285
ENSMUST00000112662	ENSMUSP00000108281
ENSMUST00000148622	ENSMUSP00000122974
ENSMUST00000141715
ENSMUST00000151941	ENSMUSP00000116792
ENSMUST00000138318
ENSMUST00000168501	ENSMUSP00000127653

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032452	histone demethylase activity
GO:0032454	histone demethylase activity (H3-K9 specific)
GO:0035064	methylated histone binding
GO:0035575	histone demethylase activity (H4-K20 specific)
GO:0051864	histone demethylase activity (H3-K36 specific)
GO:0071558	histone demethylase activity (H3-K27 specific)

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0007420	brain development
GO:0033169	histone H3-K9 demethylation
GO:0035574	histone H4-K20 demethylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045943	positive regulation of transcription from RNA polymerase I promoter
GO:0055114	oxidation-reduction process
GO:0061188	negative regulation of chromatin silencing at rDNA
GO:0070544	histone H3-K36 demethylation
GO:0071557	histone H3-K27 demethylation