Mus musculus Gene: Phf8
Summary
InnateDB Gene IDBG-179199.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phf8
Gene Name PHD finger protein 8
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041229
Encoded Proteins
PHD finger protein 8
PHD finger protein 8
PHD finger protein 8
PHD finger protein 8
PHD finger protein 8
PHD finger protein 8
PHD finger protein 8
PHD finger protein 8
PHD finger protein 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172943:
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:151520672-151633859
Strand Forward strand
Band F3
Transcripts
ENSMUST00000046962 ENSMUSP00000041312
ENSMUST00000046950 ENSMUSP00000040765
ENSMUST00000112670 ENSMUSP00000108289
ENSMUST00000112668 ENSMUSP00000108287
ENSMUST00000112666 ENSMUSP00000108285
ENSMUST00000112662 ENSMUSP00000108281
ENSMUST00000148622 ENSMUSP00000122974
ENSMUST00000141715
ENSMUST00000151941 ENSMUSP00000116792
ENSMUST00000138318
ENSMUST00000168501 ENSMUSP00000127653
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032452 histone demethylase activity
GO:0032454 histone demethylase activity (H3-K9 specific)
GO:0035064 methylated histone binding
GO:0035575 histone demethylase activity (H4-K20 specific)
GO:0051864 histone demethylase activity (H3-K36 specific)
GO:0071558 histone demethylase activity (H3-K27 specific)
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0007420 brain development
GO:0033169 histone H3-K9 demethylation
GO:0035574 histone H4-K20 demethylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045943 positive regulation of transcription from RNA polymerase I promoter
GO:0055114 oxidation-reduction process
GO:0061188 negative regulation of chromatin silencing at rDNA
GO:0070544 histone H3-K36 demethylation
GO:0071557 histone H3-K27 demethylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell Cycle, Mitotic pathway
Chromatin organization pathway
HDMs demethylate histones pathway
Cell Cycle pathway
M Phase pathway
Condensation of Prophase Chromosomes pathway
Chromatin modifying enzymes pathway
Mitotic Prophase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
HDMs demethylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.17156 Mm.474866
RefSeq NM_001113354 NM_177201 XM_006528875 XM_006528876 XM_006528877 XM_006528880
OMIM
CCDS CCDS30470 CCDS53223
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas