InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pip5k1b

Summary

InnateDB Protein

IDBP-255519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pip5k1b

Protein Name

phosphatidylinositol-4-phosphate 5-kinase, type 1 beta

Synonyms

PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta; Pipk5b; STM7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108292

InnateDB Gene

IDBG-154627 (Pip5k1b)

Protein Structure

UniProt Annotation

Function

Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion. {ECO:0000269PubMed:10679324, ECO:0000269PubMed:18772378, ECO:0000269PubMed:8798574}.

Subcellular Localization

Endomembrane system {ECO:0000250}. Note=Associated with membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain and testis. Barely detectable in liver and skeletal muscle. {ECO:0000269PubMed:8798574}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016307	phosphatidylinositol phosphate kinase activity
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity

Biological Process

GO:0046488	phosphatidylinositol metabolic process
GO:0046854	phosphatidylinositol phosphorylation

Cellular Component

GO:0001931	uropod
GO:0012505	endomembrane system
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:107930

InterPro

IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup

PFAM

PF01504

PRINTS

PIRSF

SMART

SM00330

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70181

PhosphoSite

PhosphoSite-P70181

TrEMBL

UniProt Splice Variant

Entrez Gene

18719

UniGene

RefSeq

MGI ID

MGI Symbol

Pip5k1b

OMIM

CCDS

HPRD

IMGT

EMBL

AF048695 AK146100 AK149354 AK164552 BC034864 D86176

GenPept

AAC05374 AAH34864 BAA13030 BAE26901 BAE28830 BAE37836