Mus musculus Protein: Cadps | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-255541.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Cadps | ||||||||||||||||||||||
Protein Name | Ca2+-dependent secretion activator | ||||||||||||||||||||||
Synonyms | AU067781; CAPS; CAPS1; mKIAA1121; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000108277 | ||||||||||||||||||||||
InnateDB Gene | IDBG-132306 (Cadps) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasmic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell junction, synapse {ECO:0000250}. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. May preferentially binds to DCVs but not to SVs. Probably localizes to different vesicles compared to CADPS2. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. {ECO:0000269PubMed:14530279, ECO:0000269PubMed:15820695}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Present in brain and adrenal glands (at protein level). Specifically expressed in neural and endocrine secretory tissues. Strongly expressed in almost all nerve cells of the brain, although it is absent from glial cells. Expressed in the cardiac atria, but not ventricles. {ECO:0000269PubMed:14530279, ECO:0000269PubMed:15820695, ECO:0000269PubMed:17984325}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:1350922 | ||||||||||||||||||||||
InterPro |
IPR000008
C2 domain IPR001849 Pleckstrin homology domain IPR010439 Calcium-dependent secretion activator |
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PFAM |
PF00168
PF00169 PF06292 |
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PRINTS |
PR00360
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PIRSF | |||||||||||||||||||||||
SMART |
SM00239
SM00233 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q80TJ1 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q80TJ1 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 27062 | ||||||||||||||||||||||
UniGene | Mm.474227 | ||||||||||||||||||||||
RefSeq | NP_001036082 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Cadps | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS36807 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC116395 AC154250 AC154592 AC156025 AK122453 AK161919 BC057065 D86214 | ||||||||||||||||||||||
GenPept | AAH57065 BAA13044 BAC65735 BAE36633 | ||||||||||||||||||||||