InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SHROOM3

Summary

InnateDB Protein

IDBP-25559.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SHROOM3

Protein Name

shroom family member 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296043

InnateDB Gene

IDBG-25553 (SHROOM3)

Protein Structure

UniProt Annotation

Function

Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, adherens junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with F-actin in stress fibers and adherens junctions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0051015	actin filament binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001843	neural tube closure
GO:0002066	columnar/cuboidal epithelial cell development
GO:0007389	pattern specification process
GO:0008360	regulation of cell shape
GO:0030036	actin cytoskeleton organization
GO:0043482	cellular pigment accumulation
GO:0045176	apical protein localization

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005912	adherens junction
GO:0016324	apical plasma membrane
GO:0043296	apical junction complex
GO:0045177	apical part of cell