InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RDH10

Summary

InnateDB Protein

IDBP-25607.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RDH10

Protein Name

retinol dehydrogenase 10 (all-trans)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000240285

InnateDB Gene

IDBG-25605 (RDH10)

Protein Structure

UniProt Annotation

Function

Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol. {ECO:0000269PubMed:12407145}.

Subcellular Localization

Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle. {ECO:0000269PubMed:12407145, ECO:0000269PubMed:14596915}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004745	retinol dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0052650	NADP-retinol dehydrogenase activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0001656	metanephros development
GO:0001701	in utero embryonic development
GO:0002138	retinoic acid biosynthetic process
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0008152	metabolic process
GO:0008406	gonad development
GO:0009887	organ morphogenesis
GO:0014032	neural crest cell development
GO:0031076	embryonic camera-type eye development
GO:0035115	embryonic forelimb morphogenesis
GO:0042572	retinol metabolic process
GO:0042574	retinal metabolic process
GO:0043583	ear development
GO:0043584	nose development
GO:0048568	embryonic organ development
GO:0048703	embryonic viscerocranium morphogenesis
GO:0055114	oxidation-reduction process
GO:0060431	primary lung bud formation
GO:0060449	bud elongation involved in lung branching