InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ace2

Summary

InnateDB Protein

IDBP-256354.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ace2

Protein Name

angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

Synonyms

2010305L05Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107890

InnateDB Gene

IDBG-184519 (Ace2)

Protein Structure

UniProt Annotation

Function

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. May have a protective role in acute lung injury. {ECO:0000269PubMed:12075344, ECO:0000269PubMed:12967627, ECO:0000269PubMed:16001071}.

Subcellular Localization

Processed angiotensin-converting enzyme 2: Secreted {ECO:0000250}.Cell membrane {ECO:0000269PubMed:23535237}; Single-pass type I membrane protein {ECO:0000269PubMed:23535237}. Cytoplasm {ECO:0000269PubMed:23535237}. Note=Detected in both cell membrane and cytoplasm in neurons.

Disease Associations

Tissue Specificity

Expressed in heart, kidney and forebrain (at protein level). Ubiquitously expressed, with highest levels in ileum, kidney and lung. In lung, expressed on vascular endothelial and airway epithelial cells. {ECO:0000269PubMed:12487024, ECO:0000269PubMed:15949646, ECO:0000269PubMed:16001071}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0001948	glycoprotein binding
GO:0004175	endopeptidase activity
GO:0004180	carboxypeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008241	peptidyl-dipeptidase activity
GO:0017046	peptide hormone binding
GO:0042277	peptide binding
GO:0046872	metal ion binding

Biological Process

GO:0003051	angiotensin-mediated drinking behavior
GO:0006508	proteolysis
GO:0009615	response to virus
GO:0032800	receptor biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0046813	receptor-mediated virion attachment to host cell
GO:0060135	maternal process involved in female pregnancy

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome