Mus musculus Protein: Klhl12 | |||||||||
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Summary | |||||||||
InnateDB Protein | IDBP-256461.6 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | Klhl12 | ||||||||
Protein Name | kelch-like 12 (Drosophila) | ||||||||
Synonyms | |||||||||
Species | Mus musculus | ||||||||
Ensembl Protein | ENSMUSP00000107851 | ||||||||
InnateDB Gene | IDBG-193821 (Klhl12) | ||||||||
Protein Structure | |||||||||
UniProt Annotation | |||||||||
Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (By similarity). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. {ECO:0000250, ECO:0000269PubMed:20970343}. | ||||||||
Subcellular Localization | Cytoplasmic vesicle, COPII-coated vesicle {ECO:0000250}. | ||||||||
Disease Associations | |||||||||
Tissue Specificity | |||||||||
Comments | |||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||
PDB ID | MGI:2385619 | ||||||||
InterPro |
IPR000210
BTB/POZ-like IPR006652 Kelch repeat type 1 IPR011333 BTB/POZ fold IPR011498 Kelch repeat type 2 IPR011705 BTB/Kelch-associated IPR013069 BTB/POZ IPR017096 Kelch-like protein, gigaxonin type |
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PFAM |
PF01344
PF07646 PF07707 PF00651 |
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PRINTS | |||||||||
PIRSF |
PIRSF037037
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SMART |
SM00225
SM00612 SM00875 |
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TIGRFAMs | |||||||||
Post-translational Modifications | |||||||||
Modification | |||||||||
Cross-References | |||||||||
SwissProt | Q8BZM0 | ||||||||
PhosphoSite | PhosphoSite-Q8BZM0 | ||||||||
TrEMBL | |||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 240756 | ||||||||
UniGene | Mm.87398 | ||||||||
RefSeq | NP_694768 | ||||||||
MGI ID | |||||||||
MGI Symbol | Klhl12 | ||||||||
OMIM | |||||||||
CCDS | CCDS35715 | ||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | AK034170 BC034514 | ||||||||
GenPept | AAH34514 BAC28614 | ||||||||