Version 5.4
Homo sapiens Protein: SEPT11
Summary
InnateDB Protein IDBP-25657.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPT11
Protein Name septin 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264893
InnateDB Gene IDBG-25655 (SEPT11)
Protein Structure
UniProt Annotation
Function Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {ECO:0000250, ECO:0000269PubMed:15196925, ECO:0000269PubMed:19234302, ECO:0000305}.
Subcellular Localization Cytoplasm, cytoskeleton. Cell junction, synapse. Cell projection, dendritic spine. Cell projection, axon {ECO:0000250}. Note=Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
Disease Associations Note=A chromosomal aberration involving SEPT11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with KMT2A/MLL1.
Tissue Specificity Widely expressed, except in leukocytes. {ECO:0000269PubMed:15196925, ECO:0000269PubMed:15915442}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0007049 cell cycle
GO:0051291 protein heterooligomerization
GO:0051301 cell division
Cellular Component
GO:0001725 stress fiber
GO:0030054 cell junction
GO:0030424 axon
GO:0031105 septin complex
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000038 Cell division protein GTP binding
IPR016491 Septin
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00735
PRINTS
PIRSF PIRSF006698
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NVA2
PhosphoSite PhosphoSite-Q9NVA2
TrEMBL
UniProt Splice Variant
Entrez Gene 55752
UniGene Hs.635257
RefSeq NP_060713
HUGO HGNC:25589
OMIM 612887
CCDS CCDS34018
HPRD 08555
IMGT
EMBL AC104687 AC111196 AK001711 AK027633 AK302700 AL110300 BC008083 BC063615 CH471057 GU727629
GenPept AAH08083 AAH63615 AAY40922 ADU87631 BAA91853 BAB55250 BAH13782 CAB53741 EAX05805

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca