InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tlr8

Summary

InnateDB Protein

IDBP-256577.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlr8

Protein Name

toll-like receptor 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107793

InnateDB Gene

IDBG-185523 (Tlr8)

Protein Structure

UniProt Annotation

Function

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B. activation, cytokine secretion and the inflammatory response (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003725	double-stranded RNA binding
GO:0003727	single-stranded RNA binding
GO:0005515	protein binding
GO:0008144	drug binding

Biological Process

GO:0001774	microglial cell activation
GO:0002224	toll-like receptor signaling pathway
GO:0002282	microglial cell activation involved in immune response
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0009615	response to virus
GO:0034158	toll-like receptor 8 signaling pathway
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045089	positive regulation of innate immune response
GO:0045356	positive regulation of interferon-alpha biosynthetic process
GO:0045359	positive regulation of interferon-beta biosynthetic process
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0050707	regulation of cytokine secretion
GO:0051607	defense response to virus
GO:0052033	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
GO:0071260	cellular response to mechanical stimulus