InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tlr8

Summary

InnateDB Gene

IDBG-185523.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlr8

Gene Name

toll-like receptor 8

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040522

Encoded Proteins

IDBP-185525

toll-like receptor 8

IDBP-256577

toll-like receptor 8

IDBP-540370

toll-like receptor 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21734241

Tlr7 and Tlr8 are translocated from the endoplasmic reticulum to the endosome in the presence of antiphospholipid antibodies, as a consequence, plasmacytoid dendritic cells become dramatically sensitized to Tlr7/8 agonists and this may play a role in systemic autoimmunity.

PMID 22393042

Tlr8 binding of HIV ssRNA induces endosomal acidification and chromatin remodeling at the TNF-alpha promoter to promote TNF-alpha release in infected macrophages. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 18985539

[Homo sapiens] TLR8 expression and function is highly up-regulated in colonic epithelium from patients with active inflammatory bowel disease (IBD), suggesting that TLR8 signalling is important in the pathogenesis of IBD.

PMID 14579267

[Homo sapiens] Toll-like receptor 8 (TLR8), 7 and 9 form a functional subgroup within the TLR family that recognizes pathogen-associated molecular patterns in endosomal/lysosomal compartments.

PMID 14976262

[Homo sapiens] TLR8 and TLR7 bind single-stranded RNA, stimulating dendritic cells (DCs) and macrophages to secrete interferon-alpha and pro-inflammatory, as well as regulatory, cytokines.

PMID 17264163

[Homo sapiens] TLR8 signalling strongly promotes inflammatory lipid mediator biosynthesis, providing novel insights on innate immune response to viral infections.

PMID 20652908

[Homo sapiens] TLR8 is activated in human monocytic cells following Helicobacter pylori phagocytosis and TLR8 single nucleotide polymorphism play a role in the modulation of TLR8-dependent microbicidal response of infected macrophages.

PMID 21734241

[Homo sapiens] TLR7 and TLR8 are translocated from the endoplasmic reticulum to the endosome in the presence of antiphospholipid antibodies, as a consequence, plasmacytoid dendritic cells become dramatically sensitized to TLR7/8 agonists and this may play a role in systemic autoimmunity.

PMID 22393042

[Homo sapiens] TLR8 binding of HIV ssRNA induces endosomal acidification and chromatin remodeling at the TNF-alpha promoter to promote TNF-alpha release in infected macrophages.

PMID 22753494

[Homo sapiens] TLR8 binds to exosomal MIR21 and MIR29A secreted by tumour cells and initiates a prometastatic inflammatory response.

PMID 24277153

[Homo sapiens] TLR8 plays a pathogenic role in disease whereby its expression is increased in patients with systemic arthritis and is correlated with the elevation of IL1B levels and disease status.

PMID 25599397

[Homo sapiens] TLR8 binds degradation products of single-stranded RNA at two distinct sites. One site prefers uridine mononucleosides and the other site prefers short oligonucleotides.

PMID 26101323

[Homo sapiens] TLR8-dependent detection of bacterial RNA is critical for triggering monocyte activation in response to infection with Streptococcus pyogenes.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101916:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:167242696-167264329

Strand

Reverse strand

Band

Transcripts

ENSMUST00000049023	ENSMUSP00000036762
ENSMUST00000112170	ENSMUSP00000107793
ENSMUST00000148370
ENSMUST00000133722	ENSMUSP00000122089
ENSMUST00000138311

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003725	double-stranded RNA binding
GO:0003727	single-stranded RNA binding
GO:0005515	protein binding
GO:0008144	drug binding

Biological Process

GO:0001774	microglial cell activation
GO:0002224	toll-like receptor signaling pathway
GO:0002282	microglial cell activation involved in immune response
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0009615	response to virus
GO:0034158	toll-like receptor 8 signaling pathway
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045089	positive regulation of innate immune response
GO:0045356	positive regulation of interferon-alpha biosynthetic process
GO:0045359	positive regulation of interferon-beta biosynthetic process
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0050707	regulation of cytokine secretion
GO:0051607	defense response to virus
GO:0052033	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
GO:0071260	cellular response to mechanical stimulus