InnateDB Protein
|
IDBP-256648.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Arhgap6
|
Protein Name
|
Rho GTPase activating protein 6
|
Synonyms
|
AI504284; RhoGAPX-1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000107755
|
InnateDB Gene
|
IDBG-185786 (Arhgap6)
|
Protein Structure
|
|
Function |
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm {ECO:0000305}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in retina and lung.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1196332
|
InterPro |
IPR000198
Rho GTPase-activating protein domain
IPR008936
Rho GTPase activation protein
|
PFAM |
PF00620
|
PRINTS |
|
PIRSF |
|
SMART |
SM00324
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O54834
|
PhosphoSite |
PhosphoSite-O54834
|
TrEMBL |
Q3TGN4
|
UniProt Splice Variant |
|
Entrez Gene |
11856
|
UniGene |
Mm.451003
|
RefSeq |
NP_001274459
|
MGI ID |
|
MGI Symbol |
Arhgap6
|
OMIM |
|
CCDS |
CCDS72472
|
HPRD |
|
IMGT |
|
EMBL |
AF012273
AF177664
AK048162
AK048507
AK077996
AK166015
AK168658
AL663026
AL663056
AL805974
AL831750
|
GenPept |
AAC53522
AAD55086
BAC33263
BAC33352
BAC37093
BAE38520
BAE40514
CAM17930
CAM17933
CAM18669
CAM21305
CAM21306
CAM21309
CAM22606
CAM22607
CAM22609
|
|
|