InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arhgap6

Summary

InnateDB Gene

IDBG-185786.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgap6

Gene Name

Rho GTPase activating protein 6

Synonyms

AI504284; RhoGAPX-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031355

Encoded Proteins

IDBP-185788

Rho GTPase activating protein 6

IDBP-185790

Rho GTPase activating protein 6

IDBP-256642

Rho GTPase activating protein 6

IDBP-256646

Rho GTPase activating protein 6

IDBP-256648

Rho GTPase activating protein 6

IDBP-627128

Rho GTPase activating protein 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000047648:
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:168795099-169304435

Strand

Forward strand

Band

Transcripts

ENSMUST00000033721	ENSMUSP00000033721
ENSMUST00000087016	ENSMUSP00000084239
ENSMUST00000112131	ENSMUSP00000107759
ENSMUST00000112129	ENSMUSP00000107757
ENSMUST00000112127	ENSMUSP00000107755
ENSMUST00000139146	ENSMUSP00000134512
ENSMUST00000143048

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0016004	phospholipase activator activity
GO:0017124	SH3 domain binding
GO:0043274	phospholipase binding

Biological Process

GO:0007015	actin filament organization
GO:0007165	signal transduction
GO:0007202	activation of phospholipase C activity
GO:0010518	positive regulation of phospholipase activity
GO:0032321	positive regulation of Rho GTPase activity
GO:0043087	regulation of GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0048041	focal adhesion assembly
GO:0051497	negative regulation of stress fiber assembly
GO:0051895	negative regulation of focal adhesion assembly

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0015629	actin cytoskeleton

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000047648

View Gene Order

ENSBTAG00000002626

Not yet available

Pathways

NETPATH

REACTOME

REACT_206918

Signaling by Rho GTPases pathway

REACT_210090

Rho GTPase cycle pathway

REACT_188257

Signal Transduction pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

KEGG

INOH

PID NCI

rhoa_reg_pathway

Regulation of RhoA activity

Cross-References

SwissProt

O54834

TrEMBL

Q3TGN4

UniProt Splice Variant

Entrez Gene

11856

UniGene

Mm.441810 Mm.451003

RefSeq

NM_178754 NM_001287530 NM_009707 XM_006528694 XM_006528695

OMIM

CCDS

CCDS41212 CCDS30534 CCDS72472

HPRD

IMGT

MGI ID

MGI:1196332

MGI Symbol

Arhgap6

EMBL

AF012273 AF177664 AK048162 AK048507 AK077996 AK166015 AK168658 AL663026 AL663056 AL805974 AL831750

GenPept

AAC53522 AAD55086 BAC33263 BAC33352 BAC37093 BAE38520 BAE40514 CAM17930 CAM17933 CAM18669 CAM21305 CAM21306 CAM21309 CAM22606 CAM22607 CAM22609

RNA Seq Atlas

11856