InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pbrm1

Summary

InnateDB Protein

IDBP-256715.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pbrm1

Protein Name

polybromo 1

Synonyms

2610016F04Rik; AI507524; BAF180; Pb1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107724

InnateDB Gene

IDBG-144501 (Pbrm1)

Protein Structure

UniProt Annotation

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0001890	placenta development
GO:0001974	blood vessel remodeling
GO:0003007	heart morphogenesis
GO:0003349	epicardium-derived cardiac endothelial cell differentiation
GO:0006351	transcription, DNA-templated
GO:0007507	heart development
GO:0008285	negative regulation of cell proliferation
GO:0016568	chromatin modification
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060948	cardiac vascular smooth muscle cell development
GO:0060979	vasculogenesis involved in coronary vascular morphogenesis