InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim71

Summary

InnateDB Protein

IDBP-257320.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim71

Protein Name

tripartite motif-containing 71

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107447

InnateDB Gene

IDBG-257318 (Trim71)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1. {ECO:0000269PubMed:19898466, ECO:0000269PubMed:22508726, ECO:0000269PubMed:22735451}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000269PubMed:19898466, ECO:0000269PubMed:22508726, ECO:0000269PubMed:22735451}.

Disease Associations

Tissue Specificity

Highly expressed in undifferentiated embryonic stem cells (ESCs). Expressed in the epiblast and in interfollicular epidermal stem cells during early development. Also expressed in male germ cells and in the reproductive tract. Highly expressed in neuroepithelial cells, and its expression declines as neurogenesis proceeds (at protein level). {ECO:0000269PubMed:19898466, ECO:0000269PubMed:22508726, ECO:0000269PubMed:22735451}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0035198	miRNA binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001843	neural tube closure
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010586	miRNA metabolic process
GO:0021915	neural tube development
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0051246	regulation of protein metabolic process
GO:0051865	protein autoubiquitination
GO:0060964	regulation of gene silencing by miRNA
GO:0071310	cellular response to organic substance
GO:0072089	stem cell proliferation
GO:2000177	regulation of neural precursor cell proliferation
GO:2000637	positive regulation of gene silencing by miRNA

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005622	intracellular

Protein Structure and Domains

PDB ID

MGI:2685973

InterPro

IPR000315 Zinc finger, B-box
IPR001258 NHL repeat
IPR001298 Filamin/ABP280 repeat
IPR001841 Zinc finger, RING-type
IPR013017 NHL repeat, subgroup
IPR014756 Immunoglobulin E-set
IPR017868 Filamin/ABP280 repeat-like

PFAM

PF00643
PF01436
PF13639
PF14634
PF00630

PRINTS

PIRSF

SMART

SM00336
SM00557
SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1PSW8