InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAD17

Summary

InnateDB Protein

IDBP-25795.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD17

Protein Name

RAD17 homolog (S. pombe)

Synonyms

CCYC; HRAD17; R24L; RAD17SP; RAD24;

Species

Homo sapiens

Ensembl Protein

ENSP00000350725

InnateDB Gene

IDBG-25785 (RAD17)

Protein Structure

UniProt Annotation

Function

Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. {ECO:0000269PubMed:10208430, ECO:0000269PubMed:11418864, ECO:0000269PubMed:11687627, ECO:0000269PubMed:11799063, ECO:0000269PubMed:12578958, ECO:0000269PubMed:12672690, ECO:0000269PubMed:14500819, ECO:0000269PubMed:14624239, ECO:0000269PubMed:15235112, ECO:0000269PubMed:15538388, ECO:0000269PubMed:21659603}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10232579, ECO:0000269PubMed:10593953, ECO:0000269PubMed:11799063, ECO:0000269PubMed:12400013}. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.

Disease Associations

Tissue Specificity

Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors). {ECO:0000269PubMed:10208430, ECO:0000269PubMed:10232579, ECO:0000269PubMed:10480350, ECO:0000269PubMed:11602352, ECO:0000269PubMed:9660800}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	53 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0000076	DNA replication checkpoint
GO:0000077	DNA damage checkpoint
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0007093	mitotic cell cycle checkpoint
GO:0008156	negative regulation of DNA replication
GO:0042325	regulation of phosphorylation