Homo sapiens Gene: RAD17
Summary
InnateDB Gene IDBG-25785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD17
Gene Name RAD17 homolog (S. pombe)
Synonyms CCYC; HRAD17; R24L; RAD17SP; RAD24;
Species Homo sapiens
Ensembl Gene ENSG00000152942
Encoded Proteins
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
RAD17 homolog (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:69369293-69414801
Strand Forward strand
Band q13.2
Transcripts
ENST00000361732 ENSP00000355226
ENST00000282891 ENSP00000282891
ENST00000354868 ENSP00000346938
ENST00000358030 ENSP00000350725
ENST00000354312 ENSP00000346271
ENST00000345306 ENSP00000311227
ENST00000305138 ENSP00000303134
ENST00000380774 ENSP00000370151
ENST00000514066
ENST00000507927 ENSP00000423060
ENST00000509734 ENSP00000426191
ENST00000511349
ENST00000521422 ENSP00000427743
ENST00000504177
ENST00000512785 ENSP00000427673
ENST00000506564 ENSP00000424696
ENST00000514626
ENST00000508320 ENSP00000424289
ENST00000513214 ENSP00000425005
ENST00000616683 ENSP00000482775
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 53 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009378 four-way junction helicase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0000076 DNA replication checkpoint
GO:0000077 DNA damage checkpoint
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007093 mitotic cell cycle checkpoint
GO:0008156 negative regulation of DNA replication
GO:0042325 regulation of phosphorylation
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G2/M Checkpoints pathway
Cell Cycle pathway
Activation of ATR in response to replication stress pathway
Cell Cycle Checkpoints pathway
KEGG
INOH
PID BIOCARTA
Role of brca1 brca2 and atr in cancer susceptibility [Biocarta view]
PID NCI
Fanconi anemia pathway
ATM pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.16184 Hs.668558 Hs.691695 Hs.739163
RefSeq NM_001278622 NM_002873 NM_133338 NM_133339 NM_133340 NM_133341 NM_133342 NM_133343 NM_133344
HUGO
OMIM
CCDS CCDS4003 CCDS4004 CCDS4005 CCDS47226
HPRD 09124
IMGT
EMBL
GenPept
RNA Seq Atlas