InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAD17

Summary

InnateDB Gene

IDBG-25785.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD17

Gene Name

RAD17 homolog (S. pombe)

Synonyms

CCYC; HRAD17; R24L; RAD17SP; RAD24;

Species

Homo sapiens

Ensembl Gene

ENSG00000152942

Encoded Proteins

IDBP-25789

RAD17 homolog (S. pombe)

IDBP-25791

RAD17 homolog (S. pombe)

IDBP-25793

RAD17 homolog (S. pombe)

IDBP-25795

RAD17 homolog (S. pombe)

IDBP-25797

RAD17 homolog (S. pombe)

IDBP-25799

RAD17 homolog (S. pombe)

IDBP-25801

RAD17 homolog (S. pombe)

IDBP-25805

RAD17 homolog (S. pombe)

IDBP-475218

RAD17 homolog (S. pombe)

IDBP-484007

RAD17 homolog (S. pombe)

IDBP-481471

RAD17 homolog (S. pombe)

IDBP-477824

RAD17 homolog (S. pombe)

IDBP-479022

RAD17 homolog (S. pombe)

IDBP-475709

RAD17 homolog (S. pombe)

IDBP-480722

RAD17 homolog (S. pombe)

IDBP-809654

RAD17 homolog (S. pombe)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:69369293-69414801

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000361732	ENSP00000355226
ENST00000282891	ENSP00000282891
ENST00000354868	ENSP00000346938
ENST00000358030	ENSP00000350725
ENST00000354312	ENSP00000346271
ENST00000345306	ENSP00000311227
ENST00000305138	ENSP00000303134
ENST00000380774	ENSP00000370151
ENST00000514066
ENST00000507927	ENSP00000423060
ENST00000509734	ENSP00000426191
ENST00000511349
ENST00000521422	ENSP00000427743
ENST00000504177
ENST00000512785	ENSP00000427673
ENST00000506564	ENSP00000424696
ENST00000514626
ENST00000508320	ENSP00000424289
ENST00000513214	ENSP00000425005
ENST00000616683	ENSP00000482775

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	53 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0000076	DNA replication checkpoint
GO:0000077	DNA damage checkpoint
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0007093	mitotic cell cycle checkpoint
GO:0008156	negative regulation of DNA replication
GO:0042325	regulation of phosphorylation

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000021635

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000002073

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

REACT_828

G2/M Checkpoints pathway

REACT_115566

Cell Cycle pathway

REACT_6769

Activation of ATR in response to replication stress pathway

REACT_1538

Cell Cycle Checkpoints pathway

KEGG

INOH

PID BIOCARTA

100234

Role of brca1 brca2 and atr in cancer susceptibility [Biocarta view]

PID NCI

fanconi_pathway

Fanconi anemia pathway

atm_pathway

ATM pathway

atr_pathway

ATR signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.16184 Hs.668558 Hs.691695 Hs.739163

RefSeq

NM_001278622 NM_002873 NM_133338 NM_133339 NM_133340 NM_133341 NM_133342 NM_133343 NM_133344

HUGO

OMIM

CCDS

CCDS4003 CCDS4004 CCDS4005 CCDS47226

HPRD

09124

IMGT

EMBL

GenPept

RNA Seq Atlas