InnateDB Protein
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IDBP-258389.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ambra1
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Protein Name
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autophagy/beclin 1 regulator 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000106948
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InnateDB Gene
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IDBG-191639 (Ambra1)
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Protein Structure
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Function |
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. {ECO:0000269PubMed:17589504}.
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Subcellular Localization |
Cytoplasmic vesicle, autophagosome {ECO:0000305PubMed:17589504, ECO:0000305PubMed:24089209}. Note=Localizes also to discrete punctae along the ciliary axoneme.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
18 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2443564
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
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PFAM |
PF00400
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PRINTS |
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
A2AH22
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PhosphoSite |
PhosphoSite-A2AH22
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
228361
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UniGene |
Mm.436667
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RefSeq |
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MGI ID |
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MGI Symbol |
Ambra1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK037516
AK083596
AK129433
AK148887
AK155513
AK169280
AL714023
AL731772
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GenPept |
BAC29823
BAC38965
BAC98243
BAE28691
BAE33303
BAE41038
CAM14517
CAM14518
CAM14519
CAM14520
CAM19280
CAM19281
CAM19282
CAM19283
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