InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ambra1

Summary

InnateDB Protein

IDBP-258389.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ambra1

Protein Name

autophagy/beclin 1 regulator 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106948

InnateDB Gene

IDBG-191639 (Ambra1)

Protein Structure

UniProt Annotation

Function

Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. {ECO:0000269PubMed:17589504}.

Subcellular Localization

Cytoplasmic vesicle, autophagosome {ECO:0000305PubMed:17589504, ECO:0000305PubMed:24089209}. Note=Localizes also to discrete punctae along the ciliary axoneme.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006914	autophagy
GO:0008285	negative regulation of cell proliferation
GO:0021915	neural tube development
GO:0030154	cell differentiation
GO:0043524	negative regulation of neuron apoptotic process