InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LY96

Summary

InnateDB Protein

IDBP-25844.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LY96

Protein Name

lymphocyte antigen 96

Synonyms

ESOP-1; ly-96; MD-2; MD2;

Species

Homo sapiens

Ensembl Protein

ENSP00000284818

InnateDB Gene

IDBG-25842 (LY96)

Protein Structure

UniProt Annotation

Function

Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001875	lipopolysaccharide receptor activity
GO:0005515	protein binding
GO:0015026	coreceptor activity

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0006968	cellular defense response
GO:0007166	cell surface receptor signaling pathway
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032497	detection of lipopolysaccharide
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087	innate immune response (InnateDB)